The long-term toxicity of n-hexane in humans is well known.[6] Extensive peripheral nervous system failure is known to occur in humans chronically exposed to levels of n-hexane ranging from 400 to 600 ppm, with occasional exposures up to 2,500 ppm. The initial symptoms are tingling and cramps in the arms and legs, followed by general muscular weakness. In severe cases, atrophy of the skeletal muscles is observed, along with a loss of coordination and problems of vision. Similar symptoms are observed in animal models. They are associated with a degeneration of the peripheral nervous system (and eventually the central nervous system), starting with the distal portions of the longer and wider nerve axons. The toxicity is not due to hexane itself but to one of its metabolites, hexane-2,5-dione. It is believed that this reacts with the amino group of the side chain of lysine residues in proteins, causing cross-linking and a loss of protein function. Chronic intoxication from hexane has been observed in recreational solvent abusers and in workers in the shoe manufacturing, furniture restoration and automobile construction industries, and recently, plastic recyclers and assemblers and cleaners of capacitive touch-screen devices.[7] In 1994, n-hexane was included in the list of chemicals on the US Toxic Release Inventory (TRI).[8] In 2001, the U.S. Environmental Protection Agency issued regulations on the control of emissions of hexane gas due to its potential carcinogenic properties and environmental concerns.[9]In February 2010, reports surfaced saying that an employee of Wintek Corporation in China, a company that manufactures touchscreen components, died in August 2009 due to hexane poisoning. Hexane was used as a replacement for alcohol for cleaning the screens. Reports suggest up to 137 Chinese employees required treatment for hexane poisoning around the same time.[14][15][16] An ABC Foreign Correspondent episode covertly interviewed several women who had been in the hospital for over six months. The women claimed that they were exposed to hexane while manufacturing iPhone hardware.[17][18] [edit]Benzene in soft drinks is of some concern due to the carcinogenic nature of the benzene molecule. This contamination is a public health concern and has caused significant outcry among environmental and health advocates. Benzene levels are regulated in drinking water nationally and internationally, and in bottled water in the United States, but only informally in soft drinks. The benzene results from decarboxylation of the preservative benzoic acid in the presence of ascorbic acid (vitamin C) especially under heat and light.
Til hlífðar öndunarfærum: Nota skal viðurkenndar öndunargrímur. Síugerð AX (lífræn efni, brún). Til hlífðar höndum: Við tíða og/eða endurtekna snertingu notið hlífðarhanska úr nítríl. Mælt er með notkun húðverndandi handáburðar (berið á áður en vinna hefst). Kannið þol hlífðarhanska áður en þeir eru notaðir í fyrsta skipti. Ath ið ð ít l óf i h f kki f ið f á þ li hlífð h k t f i n-Hexan Athugið að ítarlegar prófanir hafa ekki farið fram á þoli hlífðarhanska gagnvart efninu. Valið byggir á bestu þekkingu og upplýsingum um innihaldsefni og upplýsingum framleiðanda hlífðarhanska. Til hlífðar augum: Þétt hlífðargleraugu með hliðarvörn til varnar slettum, eða andlitshlíf. Til hlífðar húð: Klæðist hlífðarfatnaði úr órafmögnuðu efni, t.d. úr bómull eða háhitaþolnu gerviefni
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